Blutplättchen: Biochemie und Physiologie

B. E. Kehrel

doi:10.1055/s-0037-1619592

Hämostaseologie, Table of Contents

Hamostaseologie 2003; 23(04): 149-158
DOI: 10.1055/s-0037-1619592

Original Article

Schattauer GmbH

Blutplättchen: Biochemie und Physiologie

Platelets: biochemistry and physiology

B. E. Kehrel

¹Experimentelle und Klinische Hämostaseologie, Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Münster

› Author Affiliations

Abstract

Zusammenfassung

Der Übersichtsartikel beschäftigt sich mit den verschiedenen Rollen der Blutplättchen in physiologischen und pathologischen Prozessen. Neben Kernprozessen der primären Hämostase, Plättchenadhäsion, Plättchensekretion, Plättchenaggregation, Gerinnselretraktion, wird die moderne Sicht der Bildung von Thrombin auf der Thrombozytenoberfläche geschildert. Ein Schwerpunkt liegt in der Darstellung der verschiedenen Signaltransduktionswege in den Plättchen.

Summary

This article reviews the roles of blood platelets in different physiologic and pathologic processes in the human body. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is presented. The different signal transduction pathways in platelets are a main focus of this review.

Schlüsselwörter

Plättchenadhäsion - Plättchenaggregation - prokoagulanter Zustand - Zell-zu-Zell-Interaktion

Keywords

Platelet adhesion - platelet aggregation - platelet procoagulant activity - platelet interaction with cells

Full Text

References

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